THE SCIENCE

What we know — and what we don't.

The science behind cellular health, NAD+, and healthy aging — written in plain language, for women who read studies and ask real questions. No hype, no shortcuts, no promises we can't keep.

CELLSHE NMN 500 bottle on a table beside glasses, an open book, and a woman reading

OUR APPROACH

How we treat the science behind our products.

The longevity supplement market has a science problem. Most brands either over-claim — citing single studies as if they proved cause-and-effect across all humans — or under-cite, leaving customers to guess what the research actually says.

We've chosen a third path. On every CELLSHE product page, we tell you exactly what each ingredient is studied for, in what doses, with what limits. We use structure/function claims — language permitted by the FDA — and mark every one with an asterisk linking to the standard FDA disclaimer. We don't say "treats." We don't say "cures." We don't say "reverses aging." Because the science doesn't support those words.

What the science does support is more interesting: a growing body of research on cellular pathways involved in healthy aging, much of it focused on NAD+ metabolism, sirtuin activity, and oxidative balance. The compounds in our products — NMN, NAD+, and Resveratrol — are among the most-studied in this field. Not because they're miracles. Because they're mechanically interesting and well-characterized.

This page collects what we've found most useful in understanding that science. It's an evolving resource. We add to it as new research is published, and we mark clearly what's emerging vs. what's well-established. If you have questions or research recommendations, email hello@cellshe.com — we read everything.

THE THREE COMPOUNDS

What the research says about NMN, NAD+, and Resveratrol.

NMN
β-Nicotinamide Mononucleotide

WHAT IT IS
A naturally-occurring compound and the most-studied precursor to NAD+. Found in foods like broccoli, avocado, and edamame, and produced internally by the body.

WHAT IT'S STUDIED FOR
Supporting NAD+ biosynthesis through the salvage pathway. Cellular energy metabolism. Mitochondrial function. Healthy aging pathways.*

WHAT'S WELL-ESTABLISHED
NMN absorption and conversion to NAD+ in human cells. NAD+ level decline with age. Mitochondrial role of NAD+ in energy production.

WHAT'S STILL BEING STUDIED
Long-term human outcomes. Optimal dosing for different demographics. Bioavailability variations.

Read more about NMN →

NAD+
Nicotinamide Adenine Dinucleotide

WHAT IT IS
A coenzyme present in every cell of the body. Central to cellular energy production and hundreds of biological processes.

WHAT IT'S STUDIED FOR
Cellular energy metabolism. Cellular maintenance pathways. Sirtuin-related pathways. Mitochondrial function.*

WHAT'S WELL-ESTABLISHED
NAD+ is essential to normal cellular life. Levels tend to decline with age. NAD+-dependent enzymes are involved in energy metabolism and cellular maintenance.

WHAT'S STILL BEING STUDIED
Oral bioavailability of NAD+ itself vs. its precursors. Different precursors' relative efficacy in different age groups.

Read more about NAD+ →

RESVERATROL
Polyphenol antioxidant

WHAT IT IS
A natural polyphenol found in plants like Japanese Knotweed and red grape skins. One of the most-studied compounds in healthy aging research over the past two decades.

WHAT IT'S STUDIED FOR
Antioxidant wellness. Cellular resilience. Sirtuin-related pathways.*

WHAT'S WELL-ESTABLISHED
Resveratrol’s antioxidant activity in vitro. Its role in sirtuin-related pathways in laboratory studies.

WHAT'S STILL BEING STUDIED
Human bioavailability (trans-Resveratrol is the bioactive form). Long-term human outcomes. Optimal dosing windows.

Read more about Resveratrol →

THE ANCHOR

NAD+ levels naturally decline with age. Here's what that actually means.

NAD+ — nicotinamide adenine dinucleotide — is a coenzyme present in every cell of your body. It is involved in cellular energy metabolism and hundreds of biological processes essential to life.

Research suggests NAD+ levels tend to decline with age, including through midlife. This isn’t a disease. It’s not a problem to “fix.” It’s a natural shift that researchers continue to study — and that many adults choose to support through daily wellness routines.

Why does this matter? NAD+ is involved in mitochondrial energy metabolism, cellular maintenance pathways, and sirtuin-related processes connected to cellular health and aging. Researchers are still working out how much age-related NAD+ decline matters for any given individual, and what level of nutritional support may be meaningful.*

Line graph showing relative NAD+ levels across adult age ranges

What the research suggests: NMN is studied for supporting NAD+ levels, Resveratrol is studied in sirtuin-related pathways, and these ingredients may complement each other within a focused healthy aging stack.*

If you want to read the foundational research yourself, we recommend starting with David Sinclair's work at Harvard Medical School, Eric Verdin's work at the Buck Institute, and the body of clinical research published in journals like Nature Aging and Cell Metabolism. We list our key resources below.

Read about our products →

GO DEEPER

Articles & deeper reads.

We're building a growing library of editorial pieces on cellular health and healthy aging — written for women in midlife who want depth without jargon. New articles are added regularly.

OUR SOURCES

Researchers, labs, and journals we follow.

We don't write the science. We translate it. Here's where we read the original research and what we recommend if you want to go deeper.

RESEARCHERS

David Sinclair, PhD
Harvard Medical School
Author of "Lifespan: Why We Age — and Why We Don't Have To"
Research focus: NAD+ biology, sirtuin pathways


Eric Verdin, MD
Buck Institute for Research on Aging
Research focus: NAD+ metabolism, mitochondrial function


Mark Mattson, PhD
Johns Hopkins School of Medicine
Research focus: Cellular stress responses, healthy aging

PEER-REVIEWED JOURNALS

Nature Aging
The leading journal on aging biology and longevity science

Cell Metabolism
Cellular and molecular biology, including mitochondrial research

Cell Reports Medicine
Translational research linking lab findings to clinical applications

PubMed (NCBI)
The primary database of peer-reviewed biomedical literature
Available free at pubmed.ncbi.nlm.nih.gov

A PRACTICAL GUIDE

How to read a longevity study yourself.

You don't need to be a scientist to read primary research.
You need to know what to look for. Here's a brief guide for evaluating the studies you'll find on NMN, NAD+, Resveratrol, or any longevity compound.

[01]

CHECK THE SAMPLE

Was the study in mice or in humans? Mice studies are interesting but don't always translate. Was it in young or old subjects? Was it in women or men? The closer the study population is to you, the more relevant the findings.

[02]

CHECK THE DOSE

At what dose was the compound studied? Is this dose realistic for human supplementation, or was it extremely high (often the case in mouse studies)? Many supplement claims are based on doses far higher than what's in commercial products.

[03]

CHECK THE DURATION

A 4-week study tells you something different than a 6-month study.
Healthy aging research often requires longer timelines. Be skeptical of short studies claiming long-term outcomes.

[04]

CHECK THE FUNDING

Who paid for the study? Industry-funded research isn't automatically biased, but it's worth knowing. Independent academic research is generally more reliable.

[05]

CHECK FOR REPLICATION

Has the finding been replicated by independent labs? A single positive study is interesting. Three independent labs finding the same thing is meaningful. Look for review articles that summarize the field, not just individual studies.

[06]

CHECK THE LIMITATIONS

Every good study acknowledges its limitations in the discussion section. If the authors are clear-eyed about what their study doesn't prove, that's a good sign. If they oversell their findings, be cautious.

CONCLUSION

We follow this checklist when we evaluate research for CELLSHE.

We share what's most useful, mark clearly what's still emerging, and never claim more than the science supports.

If you'd like to discuss a specific study or finding, write to us at hello@cellshe.com.

APPLY THE SCIENCE

The science is the foundation. The products are the application.

We've built CELLSHE's three foundational products — NMN 500, NAD+, and Resveratrol 600 — to translate this body of research into practical, daily supplementation.
Meaningful daily servings, radical transparency, third-party tested.

EXPLORE THE COLLECTION →

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*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

CELLSHE products are intended for healthy adults. Consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, take medications, or have a medical condition. Not for use by individuals under 18 years of age. Keep out of reach of children. Discontinue use and consult a healthcare professional if any adverse reaction occurs.